The St. Petersburg-Warsaw Tract (road) through the town was crucial for the growth and development of the economy of Jonava. It connected the town with Kaunas, Ukmergė, Daugavpils and other cities. The Jonava horse post station is an important element of the infrastructure of this route. The construction of the complex dates back to 1833-1835. The post office complex consists of two outbuildings and a small former dwelling house with a cross corridor. The façade of the main block is accentuated by a portico with four Doric columns on the road side. The complex stands at a compositional and visual point of importance in the city, on the axis linking the Neris River bridge and the road bypassers' house behind it (currently a pizzeria)

In terms of the number of buildings, size and services provided, the Jonava Horse Post Office belonged to the third class. The station handled mail and freight parcels as well as passengers travelling by horse-drawn carriage. The road was used by high-ranking passengers, civil servants, merchants and travellers from many cities in Russia and Western Europe. In 1844, the post office had 25 horses, and in 1860, the post office owned as many as 51 animals.

There were rest rooms for members of the Tsar's family and officials. There was a waiting room in the main building. There were stables and feed stores. In 1905, a fire broke out in the town and within 15 minutes had engulfed the entire centre of the town. The fire also severely damaged the post office complex. The post office complex probably acquired its inter-war appearance and its present roof silhouettes after the reconstruction following the fire of 1905.

After the First World War, the post office ceased to function. In the interwar period, the main building housed the Jonava Post, Telegraph and Telephone Office. During the Second World War, the post office was again on fire, especially the central block. After the war, it housed the Jonava communications hub. From 1974 to 1991, the buildings housed the Jonava Central District Library, and since 1992 the Jonava Regional Museum has been open in the old post office. Since 2006, the Jonava Tourism Information Centre has been operating in the complex.