In interwar Tauragė, smaller museums were established in educational institutions: the Teachers' Seminary and the School of Commerce. In the post-war years, teachers and cultural workers continued to collect historical and ethnographic material, folklore, and encouraged students to get to know their homeland. Since 1965 The Polytechnic Museum operated in Tauragė Castle. The Santaka Museum has been operating since 1990. September 1 At that time, the museologists consulted with the heads of schools and organizations about the transfer of their museum collections. The exhibits obtained formed the beginning of the sets. There are now more than 20,000 exhibits in the museum's collection.

Currently, Tauragė Region Museum "Santaka" consists of archeology, history, ethnography, nature expositions, a photo gallery, castle arts, and the "Tower of the Ages" full of innovations. Skaudvilė Region Museum, Alfonsas Čepauskas Art Gallery and the Exile and Resistance Museum are departments of Tauragė Region Museum.